Home phcog j, vol 9, issue 6, novdec, 2017 hypoglycemic and hypolipidemic activities of ethanolic extract from mimosa pudica l. Pathophysiological changes of the lower urinary tract. Pdf protein isolate from parkia biglobosa seeds improves. Esculin improves dyslipidemia, inflammation and renal. Increasing studies have shown that dyslipidemia and inflammatory responses play important roles in the progression of microvascular diabetic complications. Wound healing in streptozotocininduced diabetic rats using atmosphericpressure argon plasma jet. Attenuation of diabetic nephropathy in streptozotocin. Nondiabetic n and streptozotocininduced diabetic d rats underwent 4h infusion of saline or sstr2a with insulin.
The present study was aimed to evaluate the retinoprotective effects of moringa oleifera mo in streptozotocininduced diabetic rats. We induced type 1 and type 2 diabetes in rats with different amounts. In the present study, we aimed to investigate the effects of celery seed extract on different biochemical factors and histopathological changes in normal and streptozotocin stzinduced diabetic rats. In the present study, it was demonstrated by histomorphological and immunohistochemical methods that magnesium sulfate administration before ischemia or following reperfusion significantly reduced renal ir injury in a diabetic rat model.
The effect of streptozotocininduced diabetes in rats on. Attenuation of diabetic nephropathy in streptozotocininduced diabetic rats by punica granatum linn. Download fulltext pdf download fulltext pdf download. Home phcog j, vol 9, issue 3, mayjun, 2017 antihyperglycemic and antihyperlipidemic effects of extract from houttuynia cordata thumb. Evaluation of antidiabetic and hypolipidemic effect of. Onion peel extracts ameliorate hyperglycemia and insulin.
To evaluate the effect of telmisartan on blood glucose levels and blood lipid levels in streptozotocin induced diabetic rats. Resveratrol, a red wine antioxidant, possesses an insulin. Metformin attenuates streptozotocininduced diabetic. The effects of quercetin liposomes qpegl on streptozotocin stzinduced diabetic nephropathy dn was investigated in rats. This study aimed to investigate how akkermansia muciniphila can implicate type 2 diabetes mellitus and the mechanisms underlying the effects a. Diabetes mellitus is a public health problem and one of the five leading. This article is from avicenna journal of phytomedicine, volume 2. This study aimed to investigate the protective effects of allicin on renal damage in streptozotocin stz. The functional insufficiency of the recovery in this period 712 months after streptozotocin application may be uncovered by the glucose tolerance test. Bmediated inflammation and apoptosis in the testes of streptozotocininduced diabetic rats. Recurrent hypoglycemia exacerbates cerebral ischemic.
Journal of biochemistry and molecular biology, vol. Antidiabetic activity of eugenia jambolana seed kernels. Normal and streptozotocininduced diabetic spraguedawley rats were orally administered with a. Research article open access dracaena arborea alleviates. Antidiabetic properties of the african mistletoe in. Pdf improvement of glycemic control in streptozotocin. The homozygous transgenic rats tgr harboring the hklk1 gene and agematched wildtype sprague dawley rats wtr were involved, and intraperitoneal injection of streptozotocin was utilized to. Male wister rats were randomly assigned to 4 groups. Abnormal cardiac function in the streptozotocininduced, noninsulindependent diabetic rat. Effect of ginger zingiber officinale extracts on blood. Metformin attenuates streptozotocininduced diabetic nephropathy in rats through. Akkermansia muciniphila can reduce the damage of gluco.
Esculin es, a coumarin derivative, was extracted from fraxinus rhynchophylla. Evaluation of antidiabetic and hypolipidemic effect of cucumis sativus fruit in streptozotocininduceddiabetic rats. Diabetes mellitus is a major manifestation of metabolic disorder which presents with hyperglycemia high levels of serum blood sugar. We determined the extent of neuronal death in ca1 hippocampus after global cerebral ischemia in control and streptozotocininduced diabetic rats. However, in vivo and in vitro studies on the effect of flavonoids on glucose metabolism have been controversial 20, 44. Effect of magnesium sulfate on renal ischemiareperfusion. Department of endocrinology, zhejiang hospital, hangzhou, 3100 china. Effect of treatment of streptozotocindiabetic rats with alogliptin on serum lipid and tbars levels and ace activity. The objective of this study is to induce experimental diabetes mellitus by streptozotocin in normal adult wistar rats via comparison of changes in body weight, consumption of food and water, volume of urine and levels of glucose, insulin and cpeptide in serum, between normal and diabetic rats. Antidiabetic effect of elephantfoot yam amorphophallus.
Streptozotocin stz is an antibiotic that produces pancreatic islet cell destruction and is widely used experimentally to produce a model of type 1 diabetes mellitus t1dm. Administration of the ethanolic extract of kernel at a concentration of 100 mgkg of body weight significantly decreased the levels of blood glucose, blood urea, and cholesterol, increased glucose. Ameliorative effects of lycium chinensis on male sexual dysfunction and testicular oxidative damage in streptozotocininduced diabetic rats. Pdf electrophysiological changes in optic neuropathy of. The present study evaluated the hypoglycemic activity of different parts of eugenia jambolana seeds such as whole seed, kernel, and seed coat on streptozotocininduced diabetic rats.
Treatment of streptozotocininduced diabetic rats with. Evaluation of antihyperglycaemic effect of leucosyke. Metformin attenuates streptozotocininduced diabetic nephropathy in rats through activation of ampk signaling pathway. For example, a polyphenolic extract of red wine has been shown to have.
Quercetin liposomes ameliorate streptozotocininduced. To investigate the protective effects and mechanisms of human tissue kallikrein 1 hklk1 on type 1 diabetes mellitus dm induced erectile dysfunction in rats. Propolis effect on streptozotocininduced diabetic rats article pdf available in journal of venomous animals and toxins including tropical diseases 1516789199. Melatonin supplementation revives diabetic induced. Endomucin restores depleted endothelial glycocalyx in the. Protein isolate from parkia biglobosa seeds improves dyslipidaemia and cardiac oxidative stress in streptozotocininduced diabetic rats. After 4 weeks of treatment, diabetic rats orally administered with live or. Regulation of podocalyxin expression in the kidney of. Data in table 2 demonstrate that serum tbars, a marker for oxidative stress, was significantly increased in diabetic rats. This study investigated the effects of rehmannia glutinosa individually as well as in combination with the oral hypoglycemic agent, metformin in streptozotocin stzinduced diabetic wistar rats.
Antihyperglycemic and antihyperlipidemic effects of. The study was continued for 24 weeks and evaluated for inflammatory tumor necrosis factor tnf. Eighteen wistar albino rats weighing 150200gms of either sex were randomly selected from the central animal facility, and divided into 3 groups. Mir20a ameliorates diabetic angiopathy in streptozotocin. Combined protective effects of malaysian propolis and metformin. Detailed in this unit are protocols for producing stz. After 5 days, dp extract 25 mgkgday and metformin 50 mgkgday were administered orally to diabetic rats for 28 days.
By employing streptozotocininduced diabetic rats and a chinese herb formulation yishen capsule, we examined the regulation of podocalyxin expression in the kidney by yishen capsule through immunofluorescent staining and reverse transcriptase polymerase chain reaction. Thus, a selective somatostatin receptor type 2 antagonist sstr2a should improve hormone counterregulation to hypoglycemia. Characterization of the antidiabetic and antioxidant. Electrophysiological changes in optic neuropathy of streptozotocin induced diabetic rats. Dp administration protected both body and organ weight loss in stztreated diabetic rats. Overexpression of emcn can restore the retinal endothelial glycocalyx of stzinduced diabetic rats. Remote ischemic preconditioning differentially attenuates. Euphorbiaceae, respectively, were supplied ad libitum to separate groups of both nondiabetic and streptozotocininduced diabetic rats, as their only source of fluid for a period of 28 days. Antidiabetic and hypolipidaemic properties of ginger. Effect of telmisartan on blood glucose levels and blood. Pdf propolis effect on streptozotocininduced diabetic rats. Hasanvand a, aminikhoei h, jahanabadi s, hadian mr, abdollahi a, tavangar sm, et al. Similarly, oral administration of porcine skin gelatin hydrolysate 300 mg per day.
Infertility is a common complication in diabetic men and experimental animals, mainly due to loss of germ cells by apoptotic cell death. Quercetin derivatives in onions have been regarded as the most important flavonoids to improve diabetic status in cells and animal models. Unlimited viewing of the articlechapter pdf and any associated supplements and figures. Li mir20a ameliorates diabetic angiopathy in streptozotocininduced diabetic rats by regulating intracellular antioxidant enzymes and vegf. This study investigates the antidiabetic activities of momordica charantia bitter gourd on streptozotocininduced type 2 diabetes mellitus in rats. Momordica charantia linn cucurbitaceae mc is used in folk medicine to treat various diseases including diabetes mellitus. Male sprague dawley rats were used to establish a stz induced dn model. Oral intake of metformin decreased the plasma glucose of stzinduced diabetic rats with a parallel increase of plasma. After 7 days, the body weight of stztreated rats was decreased by more than onethird p pdf streptozotocininduced diabetic models in mice and rats streptozotocin stz is an antibiotic that can cause pancreatic. Pdf wound healing in streptozotocininduced diabetic. Department of biochemistry and nutrition, csir central food technological research institute, mysore, 570020 india.
Diabetes, melatonin, hematology, hepatorenal, antioxidative status, biochemistry, streptozotocin. Furthermore, emcn overexpression can decrease leukocyteendothelial adhesion to ameliorate inflammation and stabilize the brb to inhibit vessel leakage in rats with dr. Hypoglycemic and hypolipidemic activities of ethanolic. Abnormal cardiac function in the streptozotocininduced. The present study was to evaluate the potential effects of es on lipid metabolism, inflammation responses and renal damage in streptozotocin stz. Nicolson in streptozotocininduced diabetic rats pdf do.
Antidiabetic effect of elephantfoot yam amorphophallus paeoniifolious dennst. In conclusion, the streptozotocininduced diabetes mellitus in rats was stable for 6 months, afterward, however, a significant recovery developed in. Antidiabetic and hypolipidaemic properties of ginger zingiber officinale in streptozotocininduced diabetic rats volume 96 issue 4 zainab m. Human tissue kallikrein 1 improves erectile dysfunction of.
The present study was aimed to examine the hypoglycemic and insulinsensitizing capacity of onion peel extract ope containing high quercetin in high fat dietstreptozotocininduced diabetic rats and to elucidate the mechanism of its insulin. Streptozotocin stz, 60 mgkg was injected intraperitoneally in rats to induce diabetes. Diabetes was induced by injecting streptozotocin intraperitonelly. Novel mechanism for plasma glucoselowering action of. The present study was aimed to evaluate the anti diabetic potential of terminalia chebula t. To better understand the insulinindependent plasma glucoselowering action of metformin, we used streptozotocin stzinduced diabetic rats to investigate the possible mechanisms. Ameliorative effects of lycium chinensis on male sexual. Catechin injection to the diabetic rats improved sod, gst, and cat activities and may be related to a decrease in free radicals generation by ctn and also increase in antioxidant content. It has been suggested that sorghum, a rich source of phytochemicals, has a hypoglycemic effect, but the mechanism is unknown. Treating diabetic rats with alogliptin lowered serum tbars, but the difference was not significant compared to untreated diabetic rats. In the present investigation, sod, gst, and cat activities were increased in ctntreated diabetic rats versus to the untreated diabetic rats.
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